What is it?
The Simulator of Human Intestinal Microbial System (SHIME®) is a scientifically validated dynamic model to study physicochemical, enzymatic and microbial parameters in the gastrointestinal tract in a controlled in vitro setting..
Manufacturer: prodigest
Model Name: NA
Applications: Upper Gut Applications Dynamic model of digestion, ability to assess the behaviour and fate of any ingestible product (e.g. the kinetics of digestion of food products Lower Gut Applications – to study of the specific roles of the mucosal and the luminal niches in the microbial community with mucosal ‘compartment’ (M-SHIME®) simulating the microenvironment of the gut wall
Instrument Overview: The SHIME® consists of a succession of five reactors simulating the different parts of the gastrointestinal tract. The first two reactors are of the fill-and-draw principle to simulate different steps in food uptake and digestion, with peristaltic pumps adding a defined amount of SHIME nutritional medium (140 mL 3x/day) and pancreatic and bile liquid (60 mL 3x/day), respectively to the stomach (V1) and duodenum (V2) compartment and emptying the respective reactors after specified intervals. The last three compartments are continuously stirred reactors with constant volume and pH control. Retention time and pH of the different vessels are chosen to resemble in vivo conditions in the different parts of the gastrointestinal tract. The overall residence time of the last three vessels, simulating the large intestine, is 72 h. Upon inoculation with fecal microbiota, these reactors simulate the ascending (V3), transverse (V4) and descending (V5) colon.
Technical features and specifications:
1. Simulation of the stomach 2. Simulation of the small intestine 3. Simulation of the different tracts of the small intestine 4. Full GIT in a single system 5. Simulation of the lower GIT 6. Maintains microbiome stability over a long timeframe: possibility to monitor microbiome adaptation to applied treatments -
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Instrument Manufacturer URL: https://prodigest.eu/
Detailed Specifications: Detailed specs if any
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