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Proteomics: Bruker ultrafleXtreme MALDI TOF

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MALDI TOF-TOF UltrafleXtreme

What is it?
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The MALDI TOF-TOF UltrafleXtreme is equipped with a 5 GS/s 10 bit digitizer for enhanced resolution and dynamic range as well as proprietary kHz smartbeam-II™ MALDI laser integrated with a novel FlashDetector™ and re-engineerd electronics to allow true 2 kHz speed in TOF mode and 1 kHz in TOF/TOF mode with a 10-bit digitizer for enhanced dynamic range and extreme flexibility that allow assessment of critical quality attributes (CQA) specifically in the area of biotherapeutic products, new modalities such as gene therapy, cell therapy, and bioprocesses, as well as microbial identification using the Bruker MALDI Biotyper System.

Manufacturer: Bruker

Model Name: MALDI TOF-TOF UltrafleXtreme

Applications: Biotherapeutics characterizations e.g. Peptide mapping with PTM, Top-down Sequencing for N-, C- terminal sequencing, disulphide linkages and protein identification, microbial identification with Biotyper

Instrument Overview: The MALDI TOF-TOF UltrafleXtreme analysis is performed in a solid state where samples are mixed with a laser absorbing matrix and then spotted and dried on a target plate. This facilitate Top-Down protein sequencing, MALDI-ISD and enable peptide and protein analysis that perform poorly in ESI-MS..

Technical features and specifications:
• Mass resolving power up to 40,000 via Bruker’s unique PAN technology for highest mass resolution across a very broad mass range.
• FlashDetector combined with a 5 GS/s 10-bit digitizer and latest advances in electronics that provide mass resolving power up to 40,000 and 1 ppm mass accuracy.
• Smartbeam™ II laser technology, with a repetition rate tunable from 1 to 2000 Hz, and an adjustable focus size from 10 μm to 80 μm.
• IR-laser based self-cleaning ion source ensures robust, long-term highest-performance operation.
• Mass range: Up to 1,000,000
• Laser Frequency, 2000hz (MS), 1000 Hz (TOF/TOF)
• MALDI Biotyper® is capable of detecting over 3,000 different bacteria and fungi species from a range of genera

Charges:
Depending on project requirement

Instrument Manufacturer URL: https://www.bruker.com/en/products-and-solutions/mass-spectrometry/maldi-tof/ultraflextreme.html

Detailed Specifications:
NA

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