Thermo Orbitrap Eclipse Tribrid MS
What is it?
The Thermo Orbitrap Eclipse Tribrid MS offers advanced Ion Management Technology (AIM+) with the new QR5 segmented quadrupole mass filter, Real-Time Search, Enhanced Vacuum Technology, Proton Transfer Charge Reduction (PTCR), and High Mass Range MSn (HMRn ) mode, that provide assessment of critical quality attributes (CQA) specifically in the area of biotherapeutic products, new modalities such as gene therapy, cell therapy, and bioprocesses, as well as proteomics analysis and process characterization in alternative protein and isolation fractionation process for food and nutrition applications.
Manufacturer: Thermo Scientific
Model Name: Orbitrap Eclipse™ Tribrid™ Mass Spectrometer
Applications: Biotherapeutics characterizations e.g. Peptide mapping with PTM, N-terminal sequencing, C-terminal sequencing, disulphide linkages and protein identification and quantitative proteome profiling for food and nutrition application.
Instrument Overview: The Thermo Orbitrap Eclipse™ Tribrid™ MS system is coupled to Waters® nanoACQUITY UPLC® M Class system or Vanquish UHPLC system for LC-MS/MS analysis at nano to micro flow rate for different type of acquisition such as SPS-MS3, PTCR MSn, High Mass Range MSn.
Technical features and specifications:
• Active Ion Management (AIM+) Technology that includes the QR5 segmented quadrupole mass filter with hyperbolic surfaces, maximizes ion transmission to achieve unprecedented levels of qualitative and quantitative performance
• Real-Time Search enables faster data acquisitions and improved specificity, significantly increasing analytical performance of TMT-based quantification experiments and Thermo Scientific™ TurboTMT mode that improves HRAM MSn acquisition rates in TMT experiments
• Thermo Scientific™ Precursor Fit filter enables precursor ion selection for a defined specificity
• Proton Transfer Charge Reduction (PTCR) simplifies MSn spectra of multiply charged analytes
• Thermo Scientific™ FAIMS Pro™ interface
• High Mass Range MSn (HMRn ) mode provides expanded mass range capabilities for comprehensive MSn characterization of intact proteins and protein complexe
• Dynamic Range: >,5000 with a single OTMS spectrum • Mass Range: Standard mass range: 50 to 2000 m/z, Mid mass range: 200 to 6000 m/z, Optemonal HMRn mass range: 500 to 8000 m/z • Mass Accuracy: Orbitrap mass accuracy: <,3 ppm RMS using external calibration <,1 ppm RMS using internal calibration • Resolution: 7500 to 500,000 (FWHM) at m/z 200 • Scan Rates: OTMSn: Up to 40 Hz ITMSn: Up to 45 Hz • Polarity Switching: One Full Cycle in <1.1 sec
Charges:
Depending on project requirement
Instrument Manufacturer URL: https://www.thermofisher.com/order/catalog/product/FSN04-10003
Detailed Specifications:
NA
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